Background:

The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization.PRX VI, a 1-Cys peroxiredoxin (also known as antioxidant protein 2 or AOP2), is highly expressed in most tissues, particularly in epithelial cells. Localized to the cell cytosol, PRX VI functions independently of other peroxiredoxins and antioxidant proteins, specializing in antioxidant defense, lung phospholipid metabolism and protection of keratinocytes from cell death induced by reactive oxygen species.

Specificity:

PRDX6 monoclonal antibody detects endogenous levels of PRDX6 protein.

Alternative names:

1-Cys PRX, aiPLA2, NSGPx, PRDX6, AOP2, KIAA0106, 1 Cys, 1 Cys peroxiredoxin, 1 Cys PRX, 1 cysPrx, 1-Cys peroxiredoxin, 1-Cys PRX, 24 kDa protein, 9430088D19Rik, AA690119, Acidic calcium independent phospholipase A2, Acidic calcium-independent phospholipase A2, aiPLA2, Antioxidant protein 2, AOP2, Aop2 rs3, Brp 12, Ciliary body glutathione peroxidase, CP 3, EC 1.11.1.15, EC 1.11.1.7, EC 3.1.1., Epididymis secretory sperm binding protein Li 128m, GPx, HEL S 128m, KIAA0106, Liver 2D page spot 40, Ltw4, Lvtw 4, MGC46173, mKIAA0106, Non selenium glutathione peroxidase, Non-selenium glutathione peroxidase, NSGPx, ORF06, OTTHUMP00000032693, p29, Peroxiredoxin-6, Peroxiredoxin6, PHGPx, Phospholipase A2 lysosomal, PLA2, PRDX 6, Prdx5, PRDX6, Prdx6 rs3, PRDX6, PRX, Red blood cells page spot 12, Thiol specific antioxidant protein,

Species reactivity:

Human

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein.

Purification & Purity:

ProG affinity purified.

Molecular weight:

25 kDa

Applications:

WB IHC ICC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:100-1:400 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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