Background:

Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway.

Specificity:

IFNAR1 monoclonal antibody detects endogenous levels of IFNAR1 protein.

Alternative names:

IFN-R-1, IFN-alpha/beta receptor 1, CRF2-1, IFNAR1, IFNAR, Alpha type antiviral protein, Antiviral protein, alpha-type, Antiviral protein, beta-type, AVP, Beta type antiviral protein, CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN alpha REC, IFN alpha receptor, IFN alpha/beta Receptor alpha, IFN beta receptor, IFN Interferon-beta receptor, IFN-alpha/beta receptor 1, IFN-R-1, IFNAR, Ifnar1, IFNBR, IFRC, INAR1, Interferon (alpha beta and omega) receptor 1, interferon alpha and beta receptor subunit 1, Interferon alpha/beta receptor 1, Interferon alpha/beta receptor alpha chain, Interferon beta receptor 1, interferon receptor 1, Interferon-alpha receptor, Type I interferon receptor 1,

Species reactivity:

Human, Mouse

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProG affinity purified

Molecular weight:

56 kDa

Applications:

WB IHC ICC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com