Background:

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.

Specificity:

HNP-1 monoclonal antibody detects endogenous levels of HNP-1 protein.

Alternative names:

HP-1, HP1, HP-2, HP2, DEFA1, DEF1, DEFA2, MRS, alpha 1, DEF1, DEF1, DEFA1, DEFA1B, DEFA2, Defensin 1, Defensin, Defensin, alpha 1, Defensin, alpha 1, myeloid related sequence, Defensin, alpha 2, HNP-1, HNP-2, HNP1, HP-1, HP-2, HP1, HP2, MRS, Myeloid related sequence, Neutrophil defensin 1, Neutrophil defensin 2,

Species reactivity:

Human, Rat

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Peptide

Purification & Purity:

ProG affinity purified

Molecular weight:

10 kDa

Applications:

WB IHC

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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