Background:

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

Specificity:

HLA Class 1 ABC monoclonal antibody detects endogenous levels of HLA Class 1 ABC protein.

Alternative names:

HLA-A, HLAA, HLA-B, HLAB, HLA-C, HLAC, Antigen presenting molecule, HLA class I histocompatibility antigen, A 1 alpha chain, HLAA, Leukocyte antigen class I A, Major histocompatibility complex, class I, A, MHC class I antigen HLA A heavy chain, AS, HLA B protein, HLA class I histocompatibility antigen, B alpha chain, HLA-B, HLA-B histocompatibility type, HLAB, leukocyte antigen class I-B, lymphocyte antigen, major histocompatibility complex, class I, B, MHC class I antigen GN00104, MHC class I antigen HLA-B heavy chain, MHC class I antigen SHCHA, MHC Class I HLA heavy chain, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, SPDA1, 1C07, Cw-7 alpha chain, D6S204, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, C alpha chain, HLA class I histocompatibility antigen, Cw-1 alpha chain, HLA JY3, HLA-C, HLA-C histocompatibility type, HLA-Cw, HLA-JY3, HLAC, HLC C, HLC-C, human leukocyte antigen-C alpha chain, major histocompatibility antigen HLA-C, major histocompatibility complex, class I, C, MHC class I antigen, MHC class I antigen Cw 1, MHC class I antigen Cw*7, MHC class I antigen heavy chain HLA-C, PSORS1 antibody

Species reactivity:

Human, Mouse, Rat

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within Human HLA Class 1 ABC aa 120-310.

Purification & Purity:

Protein affinity purified.

Molecular weight:

40 kDa

Applications:

WB ICC IHC

Usage:

WB:1:500-1:2,000 ICC:1:50 IHC:1:50-1:200

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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