Background:

The glucocorticoid receptor (GR) is a ubiquitously expressed transcription factor that mediates the effects of glucocorticoids. The most abundant isoform is GR α. GR induces or represses the expression of genes in response to glucocorticoids, mediating such processes as apoptosis, cell growth and differentiation. A significant class of genes suppressed by GR is controlled by the transcription factor AP-1. GR has also been shown to be the limiting factor in the induction of gene expression by glucocorticoids. It has been revealed that GR forms a complex with HSP 90, rendering the non-ligand bound receptor transcriptionally inactive. More importantly, mutant GRs lacking the signaling domain remain constitutively active.

Specificity:

GR monoclonal antibody detects endogenous levels of GR protein.

Alternative names:

GR, NR3C1, GRL, GCCR, GCR, Glucocorticoid receptor alpha isoform, Glucocorticoid receptor, GR, GRL, NR3C1, Nuclear receptor subfamily 3 group C member 1,

Species reactivity:

Human

Host:

Mouse

Ig type:

Mouse IgG2a, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length protein corresponding to Human Glucocorticoid Receptor alpha.

Purification & Purity:

ProG affinity purified.

Molecular weight:

86 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:1,000-1:5,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com