Background:

Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.

Specificity:

ALDH4A1 monoclonal antibody detects endogenous levels of ALDH4A1 protein.

Alternative names:

P5C dehydrogenase, ALDH4A1, ALDH4, P5CDH, AL4A1, aldehyde dehydrogenase 4, aldehyde dehydrogenase 4 family, member A1, Aldehyde dehydrogenase family 4 member A1, Aldehyde dehydrogenase, family 4, subfamily A, member 1, ALDH4, aldh4a1, Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial, Delta-1-pyrroline-5-carboxylate dehydrogenase, L-glutamate gamma-semialdehyde dehydrogenase, mitochondrial, mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase, P5C dehydrogenase, P5CD, P5CDh, P5CDhL, P5CDhS, Pyrroline-5-carboxylate dehydrogenase, RP11 128M10.1,

Species reactivity:

Human, Rat

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide of C terminal human ALDH4A1.

Purification & Purity:

ProG affinity purified.

Molecular weight:

62 kDa

Applications:

WB IHC

Usage:

WB:1:1,000-1:2,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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