Background:

Caveolin, an integral membrane protein, is a principal component of caveolae membranes in vivo. Two isoforms of caveolin have been identified: a slower migrating 24-kDa species ( -isoform) and a faster migrating 21-kDa species ( -isoform). Caveolins interact with multiple signaling molecules, such as the G-protein alpha subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases and eNOS. Caveolin-1 has been implicated in the pathogenesis of mammary epithelial cell hyperplasia.

Specificity:

This antibody detects endogenous levels of Caveolin-1 and does not cross-react with related proteins.

Alternative names:

Caveolin 1; Caveolin1; CAV1; CAV

Species reactivity:

Human,Mouse,Rat

Host:

Mouse

Ig type:

Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

This antibody is produced by immunizing mice with a synthetic peptide (KLH-coupled) corresponding to caveolin-1.

Purification & Purity:

Protein A affinity purified

Molecular weight:

~ 20 kDa

Applications:

WB ICC IHC

Usage:

WB: 1:500 IHC/ICC: 1:100-1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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