Background:

Bmi-1 has been identified as a potent oncogene as it contributes to the transcriptional activation of genes implicated in early lymphoid development. Proviral activation of Bmi-1 expression corresponds to enhanced gene-specific activation of other proto-oncogenes, including c-Myc and Pim, subsequently resulting in the progression of lymphomagenesis.

Specificity:

This antibody detects endogenous levels of Bmi1 and does not cross-react with related proteins.

Alternative names:

Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; BMI1; PCGF4; RNF51

Species reactivity:

Human,Mouse,Rat

Host:

Mouse

Ig type:

Mouse IgG2a, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

This antibody is produced by immunizing mice with a recombinant protein corresponding to a region of Bmi1.

Purification & Purity:

Protein A affinity purified

Molecular weight:

~ 37 kDa

Applications:

WB ICC IHC FC

Usage:

WB: 1:1000 IHC/ICC: 1:100-1:200 FC: 1:100-1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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