Background:

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.

Specificity:

This antibody detects endogenous levels of TBL1 and does not cross-react with related proteins.

Alternative names:

F-box-like/WD repeat-containing protein; TBL1X; SMAP55; Transducin beta-like protein 1X; Transducin-beta-like protein 1, X-linked; TBL1X; TBL1

Species reactivity:

Human

Host:

Mouse

Ig type:

Mouse IgG2b, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Purified recombinant human TBL1 protein fragments expressed in E.coli.

Purification & Purity:

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

Predicted band size:58KDa Observed band size:58KDa

Applications:

WB ICC

Usage:

WB: 1:1000 ICC: 1:100~500

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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