Background:

In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases, specifically PP1 (protein phosphhatase 1), which is targeted to different substrates throughout the cell. Phostensin, also known as KIAA1949, is a 613 amino acid protein that localizes to both the cytoplasm and the cytoskeleton. Expressed predominately in spleen, ovary, lung and liver tissue, phostensin functions as a regulatory subunit that interacts with and targets PP1 to F-Actin in the cytoskeleton. Two isoforms of phostensin exist due to alternative splicing events.

Specificity:

This antibody detects endogenous levels of Phostensin and does not cross-react with related proteins

Alternative names:

HKMT1098; KIAA1949; Protein phosphatase 1 F actin cytoskeleton targeting subunit.; PPP1R18;

Species reactivity:

Human

Host:

Mouse IgG1

Ig type:

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human Phostensin.

Purification & Purity:

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

Predicted band size:120KDa Observed band size:120KDa

Applications:

WB

Usage:

WB: 1:200~1000

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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