Background:

This gene encodes an antagonist of bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal angiogenesis in response to hypoxia. Alternatively spliced transcript variants encoding different isoforms have been described. Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embyonic bone formation By similarity. May also play an important role in regulating retinal angiogenesis trough modulation of BMP4 actions in endothelial cells.

Specificity:

CHRDL1 mAb detects endogenous levels of CHRDL1 protein.

Alternative names:

Neuralin-1 Neurogenesin-1 Ventroptin; CHL; VOPT; NRLN1; dA141H5.1

Species reactivity:

Human,Mouse,Rat

Host:

Mouse IgG1

Ig type:

1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant full length Human CHRDL1.

Purification & Purity:

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

Predicted band size:57kDa Observed band size:57kDa

Applications:

WB ICC

Usage:

WB: 1:1000 ICC: 1:300

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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