Background:

UNC84A (UNC84 homolog A), also known as SUN1, is a multi-pass nuclear membrane protein that is involved in nuclear anchoring and migration. Highly expressed in heart, brain and testis, UNC84A functions as an A-type Lamin-binding protein that forms a link between the inner and outer nuclear envelope membranes. This link acts as a structural bridge between the nuclear interior and the Actin cytoskeleton and is essential for proper localization of nuclear envelope proteins. Additionally, UNC84A may be involved in telomere attachment and in normal testis development. UNC84A contains one UNC84 (SUN) domain and exists as four isoforms due to alternative splicing events.

Specificity:

This antibody detects endogenous levels of SUN1 and does not cross-react with related proteins.

Alternative names:

SUN domain-containing protein 1; Protein unc-84 homolog A; Sad1/unc-84 protein-like 1; SUN1; KIAA0810; UNC84A

Species reactivity:

Human,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein corresponding to C-terminal human SUN1.

Purification & Purity:

Protein A affinity purified.

Molecular weight:

~ 90 kDa

Applications:

WB IHC ICC FC

Usage:

WB: 1:500-1:2000 IHC: 1:50-1:200 ICC: 1:50-1:200 FC: 1:50-1:100

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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