Background:

WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.

Specificity:

WASF2 polyclonal antibody detects endogenous levels of WASF2 protein.

Alternative names:

WASP family protein member 2, WASF2, DICTYOSTELIUM, dJ393P12.2, IMD2, Protein WAVE-2, Putative Wiskott Aldrich syndrome protein family member 4, SCAR 2, SCAR, SCAR2, Suppressor of cyclic-AMP receptor (WASP family), Verprolin homology domain-containing protein 2, WASF2, WASF2, WASF4, WASP family protein member 2, WASP family protein member 4, WASP family Verprolin homologous protein 2, WASP-family protein member 2, WAVE 2, WAVE2, Wiskott-Aldrich syndrome protein family member 2, Wiskott-Aldrich syndrome protein family verprolin-homologous protein,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

54 kDa

Applications:

WB IHC

Usage:

WB:1:1,000-1:5,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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