Background:

T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4, also designated VTCN1), belongs to the B7 Immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells supresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.

Specificity:

VTCN1 polyclonal antibody detects endogenous levels of VTCN1 protein.

Alternative names:

B7-H4, VTCN1, B7H4, B7 family member, H4, B7 H4, B7 homolog 4, B7 superfamily member 1, B7 superfamily, member 1, B7-H4, B7h.5, B7h4, B7S1, B7x, BC032925, Immune costimulatory protein B7-H4, Immune costimulatory protein B7H4, MGC41287, PRO1291, Protein B7S1, RP11 229A19.4, T cell costimulatory molecule B7x, T-cell costimulatory molecule B7x, V set domain-containing T cell activation inhibitor 1, V-set domain-containing T-cell activation inhibitor 1, VCTN1, Vtcn1, VTCN1,

Species reactivity:

Human, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein with human B7-H4 aa 50-220.

Purification & Purity:

Protein affinity purified.

Molecular weight:

31/21/10 kDa (Predicted band size)

Applications:

WB ICC IHC FC

Usage:

WB:1:500-1:2000 ICC:1:1,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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