Background:

MaxiKβ subunit 1 consists of two putative transmembrane domains, an extracellular loop containing three consensus sequences for N-linked glycosylation and four cysteine residues that might form disulfide bridges. MaxiKβ subunit 1, one of four subunits in the MaxiKβ family, is expressed predominately in smooth muscle tissue but is also found in brain, liver and lymphatic tissues. MaxiKβ subunit 1 associates with MaxiKα to form a calcium-activated potassium channel (also designated MaxiK and BK channel). MaxiKβ subunit 1 increases the sensitivity of the MaxiKα to calcium and voltage. The MaxiKα/β1 channel is the most sensitive of all Maxi channels to calcium. MaxiKβ plays an important role in vasoregulation by controlling the sensitivity of MaxiK channels to calcium, which leads to the proper amount of arterial relaxation.

Specificity:

MaxiKβ2 (I186) polyclonal antibody detects endogenous levels of MaxiKβ2 protein.

Alternative names:

Calcium-activated potassium channel subunit beta-2; BK channel subunit beta-2; BKbeta2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Calcium-activated potassium channel subunit beta; Charybdotoxin receptor subunit beta-2; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2; Slo-beta2; KCNMB2; Calcium-activated potassium channel subunit β-2; BK channel subunit β-2; BKβ2; BKβ2; Hβ2; Calcium-activated potassium channel, subfamily M subunit β-2; Calcium-activated potassium channel subunit β2; Charybdotoxin receptor subunit β-2; K(VCA)β-2; Maxi K channel subunit β-2; Slo-β-2; Slo-β2;

Species reactivity:

Human,Mouse,Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 154-203 of Human MaxiKβ2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 27 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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