Background:

Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration.

Specificity:

USP9x polyclonal antibody detects endogenous levels of USP9x protein.

Alternative names:

hFAM, USP9X, DFFRX, FAM, USP9, Deubiquitinating enzyme FAF X, Deubiquitinating enzyme FAF-X, DFFRX, Drosophila fat facets related X linked, FAF, Fafl, Fam, Fat facets homolog, Fat facets in mammals, Fat facets protein related X linked, Fat facets protein related, X-linked, Fat facets protein-related, hFAM, MRX99, Probable ubiquitin carboxyl terminal hydrolase FAF X, Probable ubiquitin carboxyl-terminal hydrolase FAF-X, Ubiquitin carboxyl-terminal hydrolase FAM, Ubiquitin specific peptidase 9 X linked, Ubiquitin specific peptidase 9, X-linked, Ubiquitin specific processing protease FAF X, Ubiquitin specific protease 9 X chromosome, Ubiquitin thioesterase FAF X, Ubiquitin thiolesterase FAF X, Ubiquitin thiolesterase FAF-X, Ubiquitin-specific protease 9, Ubiquitin-specific-processing protease FAF-X, USP9 (gene name), Usp9x, USP9X, Uubiquitin specific protease 9, X chromosome (fat facets like Drosophila), X chromosome, X-linked,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human USP9X aa 1-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

292 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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