Background:

HAUSP (herpesvirus-associated ubiquitin-specific protease, USP7) is a ubiquitin-specific protease. HAUSP localizes predominantly to the nucleus, in a TD-dependent manner, where it associates with ND10. ND10 are small nuclear structures implicated in a variety of cellular processes including response to stress and interferons, oncogenesis, and viral infection. HAUSP binds strongly to Vmw110, a herpesvirus regulatory protein which has the ability to disrupt ND10. HAUSP, a novel p53-interacting protein, functions to deubiquitinize p53 in an important pathway for p53 stabilization. HAUSP strongly stabilizes p53 even in the presence of excess Mdm2, and also induces p53-dependent cell growth repression and apoptosis. The HAUSP protein is distributed in the nucleus in a micropunctate pattern with a limited number of larger discrete foci, some of which co-localize with PML in ND10. The gene encoding HAUSP maps to human chromosome band 16p13.2.

Specificity:

USP7 polyclonal antibody detects endogenous levels of USP7 protein.

Alternative names:

, Deubiquitinating enzyme 7, HAUSP, Herpes virus associated ubiquitin specific protease, Herpesvirus-associated ubiquitin-specific protease, TEF 1, tef-1, TEF1, Ubiquitin carboxyl terminal hydrolase 7, Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin specific peptidase 7 (herpes virus associated), Ubiquitin specific peptidase 7, Ubiquitin specific peptidase 7 herpes virus associated, Ubiquitin specific processing protease 7, Ubiquitin specific protease 7 (herpes virus associated), Ubiquitin specific protease 7, Ubiquitin specific protease 7 herpes virus associated, Ubiquitin thioesterase 7, Ubiquitin thiolesterase 7, Ubiquitin-specific-processing protease 7, UBP 7, UBP-7, UBP7, UBP7, USP 7, usp-7, Usp7, VMW110-ASSOCIATED PROTEIN, 135-KD,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human USP7 aa 100-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

128 kDa

Applications:

WB IHC FC

Usage:

WB:1:500-1:1,000 IHC:1:50 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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