Background:

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP21 (ubiquitin specific peptidase 21), also known as USP16 or USP23, is a 565 amino acid protein that belongs to the C19 peptidase family of ubiquitin carboxy-terminal hydrolases. Capable of removing ubiquitin from ubiquitinated proteins, USP21 plays a role in signal transduction and can also remove NEDD8 from NEDD8-conjugated proteins, possibly functioning to influence NEDD8-mediated protein proteolysis. Multiple isoforms of USP21 exist due to alternative splicing events.

Specificity:

USP21 polyclonal antibody detects endogenous levels of USP21 protein.

Alternative names:

USP21, USP23, PP1490, Deubiquitinating enzyme 21, deubiquitinating enzyme 23, EC 3.1.2.15, ESTM28, MGC3394, NEDD8-specific protease, Ubiquitin carboxyl terminal hydrolase 21, ubiquitin carboxyl terminal hydrolase 23, Ubiquitin carboxyl-terminal hydrolase 21, ubiquitin specific peptidase 21, Ubiquitin specific processing protease 21, ubiquitin specific protease 16, ubiquitin specific protease 21, ubiquitin specific protease 23, Ubiquitin thioesterase 21, Ubiquitin thiolesterase 21, ubiquitin thiolesterase 23, ubiquitin-specific protease 23, formerly, Ubiquitin-specific-processing protease 21, UBP21, USP16 antibodyv Usp21, USP23, USP23, formerly, W53272,

Species reactivity:

Human, Rat, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Peptide

Purification & Purity:

Peptide affinity purified

Molecular weight:

63 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500 ICC:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com