Background:

ULK1 and ULK2 (for UNC-51-like kinase) encode similar amino-terminal serine/threonine kinase domains, a proline/serine-rich (PS) domain, and a species conserved carboxyl-terminal domain. Both share homology with the UNC-51 kinase from Caenorhabditis elegans and the APG1 kinase in yeast, which are involved in axonal extension and growth, and autophagy, respectively. ULK1 maps to human chromosome 12q24.3 and is ubiquitously expressed. ULK2, also widely expressed, maps to mouse chromosome 11B1.3 and is expected to have a similar molecular weight as ULK1 in human. ULK1 and ULK2 are thought to auto-phosphorylate the PS domain in vitro, and the significant homology among vertebrates suggest that ULK1 and ULK2 are involved in the regulation of fundamental biological processes (1,2,6).

Specificity:

ULK1 polyclonal antibody detects endogenous levels of ULK1 protein.

Alternative names:

ATG1, hATG1, ULK1, KIAA0722, ATG 1, ATG1, ATG1 autophagy related 1 homolog, ATG1A, Autophagy related protein 1 homolog, Autophagy-related protein 1 homolog, FLJ38455, FLJ46475, hATG1, KIAA0722, Serine/threonine protein kinase ULK1, Serine/threonine protein kinase Unc51.1, Serine/threonine-protein kinase ULK1, ULK 1, ULK1, ULK1, Unc 51 (C. elegans) like kinase 1, UNC 51, Unc 51 like kinase 1, Unc-51 like kinase 1 (C. elegans), Unc-51-like kinase 1, UNC51, UNC51, C. elegans, homolog of, Unc51.1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

Protein affinity purified.

Molecular weight:

113 kDa

Applications:

ICC IHC FC WB

Usage:

WB:1:500 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com