Background:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Specificity:

TXNIP polyclonal antibody detects endogenous levels of TXNIP protein.

Alternative names:

TXNIP, VDUP1, EST01027, HHCPA78, THIF, Thioredoxin binding protein 2, Thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, TXNIP, TXNIP, Upregulated by 1, 25 dihydroxyvitamin D 3, VDUP1, Vitamin D3 up-regulated protein 1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

44 kDa

Applications:

WB ICC/IF IHC FC

Usage:

WB:1:1000-1:5,000 ICC/IF:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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Email: info@sobekbio.com

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