Background:

Fn14, the TWEAK receptor, is a recently identified member of the TNF receptor superfamily and is expressed on smooth muscle cells and endothelial cells. It is a weak inducer of apoptosis and promotes angiogenesis. Fn14 is a type 1 membrane protein. It associates with TRAF1 and TRAF2, and may modulate cellular adhesion to matrix proteins. Fn14 is highly expressed in heart, placenta and kidney, and moderately expressed in lung, skeletal muscle and pancreas. It is the smallest member of the TNF receptor (TNFR) superfamily described to date, and signals via recruitment of several different TNFR-associated factors.

Specificity:

TWEAKR polyclonal antibody detects endogenous levels of TWEAKR protein.

Alternative names:

FGF-inducible 14, TweakR, TNFRSF12A, FN14, CD 266, CD266, CD266 antigen, FGF inducible 14, FGF-inducible 14, Fibroblast growth factor inducible immediate early response protein 14, Fibroblast growth factor-inducible immediate-early response protein 14, FN 14, FN14, TNFRSF 12A, TNFRSF12A, TNR12, Tumor necrosis factor receptor superfamily member 12A, TWEAK R, Tweak receptor, Tweak-receptor, TweakR,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide within human TWEAKR aa 80-120.

Purification & Purity:

Peptide affinity purified.

Molecular weight:

14 kDa

Applications:

ICC IHC FC

Usage:

ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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