Background:

A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IkB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.

Specificity:

TNFAIP3 polyclonal antibody detects endogenous levels of TNFAIP3 protein.

Alternative names:

TNF alpha-induced protein 3, TNFAIP3, OTUD7C, A20, AISBL, MGC104522, MGC138687, MGC138688, OTU domain containing protein 7C, OTU domain-containing protein 7C, OTUD7C, Putative DNA binding protein A20, Putative DNA-binding protein A20, TNAP3, TNF alpha-induced protein 3, TNFA1P2, TNFAIP 3, TNFAIP3 (A20), TNFAIP3, Tumor necrosis factor alpha induced protein 3, Tumor necrosis factor alpha-induced protein 3, Tumor necrosis factor induced protein 3, Tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha-induced protein 3, Zinc finger protein A20,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

90 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com