Background:

The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. Caspase-associated recruitment domains (CARDs) mediate the interaction between adaptor proteins such as Apaf-1 and the proform of caspases (e.g., CASP9) participating in apoptosis. ASC (apoptosis-associated speck-like protein containing a CARD, also known as TMS1or PYCARD) is a member of the CARD-containing adaptor protein family. ASC is a 195 amino acid protein, containing a N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal CARD. This motif is characteristic of numerous proteins involved in apoptotic signaling. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation.

Specificity:

TMS1 polyclonal antibody detects endogenous levels of TMS1 protein.

Alternative names:

hASC, PYCARD, ASC, CARD5, Apoptosis associated speck like protein containing a CARD, Apoptosis-associated speck-like protein containing a CARD, ASC, ASC, CARD 5, CARD5, Caspase recruitment domain containing protein 5, Caspase recruitment domain protein 5, Caspase recruitment domain-containing protein 5, hASC, MGC10332, PYCARD, PYD and CARD domain containing, PYD and CARD domain containing protein, PYD and CARD domain-containing protein, Target of methylation induced silencing 1, Target of methylation-induced silencing 1, TMS 1, TMS, TMS1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

22 kDa

Applications:

WB ICC/IF FC

Usage:

WB:1:500-1:1,000 ICC:1:100-1:500 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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Email: info@sobekbio.com

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