Background:

TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases 1, 2, 3 and 4) complex with metalloproteinases such as collagenases, gelatin-ases and stromelysins, resulting in irreversible inactivation of the metallopro-teinase. TIMP-1 has been found to be identical to EPA (erythroid-potentiation activity). Parathyroid hormone has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus and remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart, with low levels expressed in liver, brain, lung, thymus and spleen.

Specificity:

TIMP2 polyclonal antibody detects endogenous levels of TIMP2 protein.

Alternative names:

TIMP-2, TIMP2, CSC 21K, CSC-21K, CSC21K, Metalloproteinase inhibitor 2, Metalloproteinase inhibitor 2 precursor, TIMP 2, TIMP metallopeptidase inhibitor 2, TIMP-2, TIMP2, TIMP2, Tissue Inhibitor of Metalloproteinase 2, Tissue inhibitor of metalloproteinases 2,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

22 kDa

Applications:

WB FC

Usage:

WB:1:500-1:2,000 FC:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com