Background:

Transforming growth factor-α (TGFα) is an acid- and heat-stable 50 amino acid protein originally found in rodents and humans. TGFα is 33% homologous at the amino acid level to epidermal growth factor (EGF). TGFα binds to the EGF receptor, mediates tyrosine phosphorylation of the receptor and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-β. TGFα is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells. TGFα bioactivity has been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.

Specificity:

TGFα polyclonal antibody detects endogenous levels of TGFα protein.

Alternative names:

TGF-alpha, ETGF, TGFA, EGF like TGF, EGF-like TGF, ETGF, TFGA, TGF A, TGF type 1, TGF-alpha, Tgfa, TGFA, Transforming growth factor alpha, Transforming growth factor alpha precursor, Wa1, Waved 1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

17 kDa

Applications:

WB ICC IF IHC IP

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

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