Background:

Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intrachain disulfide bonds, forming the trefoil motif, or P-domain. pS2, also designated Md2, BCEI, TFF1 and pNR-2, is a trefoil protein that is highly expressed in normal gastric mucosa. pS2 has also been detected in a number of carcinomas including cancers of the breast, pancreas and stomach. pS2 is not present in normal breast tissue but is inducible by estrogen in MCF7 cells. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. The gene encoding pS2 maps to human chromosome 21q22.3.

Specificity:

TFF1 polyclonal antibody detects endogenous levels of TFF1 protein.

Alternative names:

hP1.A, BCEI, PS2, TFF1, BCEI, Breast cancer estrogen inducible protein, Breast cancer estrogen inducible sequence, Breast cancer estrogen-inducible protein, D21S21, Gastrointestinal trefoil protein, Gastrointestinal trefoil protein pS2, hP1.A, HP1A, HPS 2, HPS2, pNR 2, PNR-2, pNR2, Polypeptide P1.A, Protein pS2, PS 2, pS2, pS2 protein, TFF 1, TFF1, TFF1, Trefoil factor 1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:500 ICC/IF:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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