Background:

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.

Specificity:

TCF7L2 polyclonal antibody detects endogenous levels of TCF7L2 protein.

Alternative names:

T-cell factor 4, TCF-4, hTCF-4, TCF7L2, HMG box transcription factor 4, hTCF 4, hTCF-4, T cell factor 4, T cell specific HMG box, T cell specific transcription factor 4, T-cell factor 4, T-cell-specific transcription factor 4, TCF 4, TCF-4, TCF4, TCF7L2, TCF7L2 protein, TF7L2, Transcription factor 7 like 2, Transcription factor 7 like 2 T cell specific HMG box, Transcription factor 7-like 2,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

68 kDa

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com