Background:

COL11A2 (collagen, type XI, alpha 2), also known as Collagen α2 Type XI, HKE5, PARP, STL3, DFNA13 or DFNB53, is a 1,736 amino acid secreted protein that contains one TSP N-terminal domain and is thought to play an essential role in fibrillogenesis, specifically by controlling the lateral growth of collagen fibrils. Defects in the gene encoding COL11A2 are the cause of Stickler syndrome type 3 (STL3), autosomal recessive otospondylomegaepiphyseal dysplasia (OSMED), Weissenbacher-Zweymueller syndrome (WZS) and non-syndromic sensorineural deafness autosomal dominant type 13 (DFNA13). Eight isoforms of COL11A2 exist due to alternative splicing events.

Specificity:

COL11A2 (P1232) polyclonal antibody detects endogenous levels of COL11A2 protein.

Alternative names:

COL11A2; Collagen alpha 2(XI); Collagen alpha-2(XI) chain; Collagen type XI alpha 2; DAQB-79P13.8; DFNA13; HGNC:2187; HKE5; PARP; STL3;

Species reactivity:

Human,Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide, corresponding to amino acids 1200-1250 of Human COL11A2.

Purification & Purity:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Molecular weight:

~ 172 kDa

Applications:

WB IHC

Usage:

WB: 1:500~1:1000 IHC: 1:50~1:200

Storage:

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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