Background:

The syntrophins are PDZ-domain-containing proteins that facilitate the recruitment of signaling proteins such as NOS1 to the dystrophin-associated protein complex. The syntrophin family are structurally related proteins that contain multiple protein interaction motifs. Syntrophins associate directly with dystrophin, the product of the Duchenne muscular dystrophy locus, and its homologs. α-Syntrophin has an important role in synapse formation and in the organization of utrophin, acetylcholine receptor and acetylcholinester-ase at the neuromuscular synapse. Specifically, NOS1 binds to α-Syntrophin at muscle sarcolemma. β2-Syntrophin is a modular adapter. In muscle cells, β2-Syntrophin interacts with members of the dystrophin family, which in-cludes utrophin.

Specificity:

Syntrophin α1 polyclonal antibody detects endogenous levels of Syntrophin α1 protein.

Alternative names:

TACIP1, SNTA1, SNT1, 59 kDa dystrophin-associated protein A1 acidic component 1, Acidic alpha 1 syntrophin, Alpha 1 syntrophin, Alpha-1-syntrophin, dJ1187J4.5, Dystrophin associated protein A1 59kDa acidic component, LQT12, OTTHUMP00000030650, Pro-TGF-alpha cytoplasmic domain-interacting protein 1, SNT1, Snta1, SNTA1, Syntrophin 1, Syntrophin-1, TACIP1,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human Syntrophin alpha 1 aa 1-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

54 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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