Background:

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Specificity:

SUV39H2 polyclonal antibody detects endogenous levels of SUV39H2 protein.

Alternative names:

H3-K9-HMTase 2, Su(var)3-9 homolog 2, SUV39H2, KMT1B, FLJ23414, H3 K9 HMTase 2, H3-K9-HMTase 2, Histone H3 K9 methyltransferase 2, Histone H3-K9 methyltransferase 2, Histone lysine N methyltransferase H3 lysine 9 specific 2, Histone lysine N methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV39H2, KMT1B, Lysine N methyltransferase 1B, Lysine N-methyltransferase 1B, sSuppressor of variegation 3 9 homolog 2 (Drosophila), Su(var)3 9 Drosophila homolog of 2, Su(var)3 9 homolog 2, Su(var)3-9 homolog 2, Suppressor of variegation 3 9 homolog 2, Suppressor of variegation 3-9 homolog 2, Suv39h2, SUV92,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide within Human SUV39H2 aa 350 to the C-terminus.

Purification & Purity:

ProA affinity purified

Molecular weight:

40/47 kDa

Applications:

WB IHC IP

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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