SUN2 polyclonal antibody BS91303
Specifications
| 50ul/100ul |
Background:
SUN2 (sad1/unc-84 protein-like 2), also known as UNC84B (unc-84 homolog B), FRIGG, KIAA0668 or RAB5IP, is a 717 amino acid single-pass membrane protein that contains one SUN domain and localizes to the membrane of both the nucleus and the endosome. Widely expressed in a variety of tissues, including lung, muscle and heart, SUN2 interacts with Rab 5A and may play a role in homotypic endosome fusion. The gene encoding SUN2 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Specificity:
SUN2 polyclonal antibody detects endogenous levels of SUN2 protein.
Alternative names:
Rab5IP, SUN2, FRIGG, KIAA0668, RAB5IP, UNC84B, FRIGG, KIAA0668, nuclear envelope protein, Protein unc-84 homolog B, Rab5 interacting protein, RAB5IP, Sad1 and UNC84 domain containing 2, Sad1 unc-84 domain protein 2, Sad1 unc84 domain protein, Sad1/unc-84 protein-like 2, Sad1/unc84 protein-like, SUN domain-containing protein 2, UNC 84B, unc84 homolog B (C. elegans), unc84 homolog B, unc84, C. elegans, homolog of, B, UNC84B,
Species reactivity:
Human, Mouse, Rat
Host:
Rabbit
Ig type:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Immunogen:
Purification & Purity:
ProA affinity purified
Molecular weight:
80 kDa
Applications:
WB IHC FC ICC IF
Usage:
WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 ICC/IF:1:50-1:100
Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.
Precautions:
For research use only, not for use in diagnostic procedure.
More info:
Email: info@sobekbio.com
Orders:
Email: orders@sobekbio.com