Background:

The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones. Members of the three groups comprising this superfamily show selectivity to certain substrate compounds. SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines, and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds. SULT2A1 catalyzes the sulfonation of procarcinogen xenobiotics, hydroxysteroids and bile acids, and is highly expressed in adrenal and liver tissues. SULT2A1 plays a role in hepatic cholesterol homeostasis. SULT2B1 consists of two isoforms, SULT2B1a and SULT2B1b, which are transcribed from the same gene by alternative splicing of their first exons. Both isoforms are highly selective for the sulphation of 3b-hydroxysteroids such as pregnenolone, epiandrosterone, DHEA and androstenediol. SULT2B1b is expressed in prostate, skin, placenta and lung.

Specificity:

SULT2A1 polyclonal antibody detects endogenous levels of SULT2A1 protein.

Alternative names:

DHEA-ST, HST, ST2A1, SULT2A1, HST, STD, Alcohol/hydroxysteroid sulfotransferase, Bile salt sulfotranasferase 2A1, Bile salt sulfotransferase, Dehydroepiandrosterone sulfotransferase, DHEA ST, DHEA sulfotranasferase, DHEA-ST, DHEAS, EC 2.8.2.14, Hst, hSTa, Hydroxysteroid sulfotransferase, ST2, ST2A1, ST2A1, ST2A3, STD, sulfotranasferase, dehydroepiandrosterone-preferring, Sulfotransferase 2A1, Sulfotransferase family 2A, dehydroepiandrosterone-preferring, member 1, Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA) preferring member 1, Sult2a1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human SULT2A1 aa 100 to the C-terminus.

Purification & Purity:

ProA affinity purified

Molecular weight:

34 kDa

Applications:

WB ICC IF IHC FC

Usage:

WB:1:500-1:1,000 ICC:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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