Background:

Su(fu) (for Suppressor-of-Fused) is a key negative regulator in the vertebrate Hedgehog signaling pathway. Su(fu) interacts with genes encoding proteins in this signal transduction pathway. In Drosophila, Intracellular transduction of the Hedgehog pathway involves the release of a large complex containing Su(fu). Su(fu) inhibits the activity of the transcription factor Gli1 and interacts with Gli2, Gli3 and the serine/threonine kinase Fused. Su(fu) is widely expressed in adult and embryonic tissues with higher expression in tissues patterned by hegdehog signaling. The Su(fu) gene locus maps to a region that is deleted in glioblastomas, prostate cancer, malignant melanoma and endometrial cancer.

Specificity:

SUFU polyclonal antibody detects endogenous levels of SUFU protein.

Alternative names:

SUFUH, OTTHUMP00000020374, OTTHUMP00000020377, OTTHUMP00000020379, PRO1280, SU FU, SU(F)U, Su(fu), SUFU, SUFU negative regulator of hedgehog signaling, SUFU, SUFUH, SUFUXL, Suppressor of fused homolog (Drosophila), Suppressor of fused homolog,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein with human SUFU aa 1-250.

Purification & Purity:

Protein affinity purified.

Molecular weight:

54 kDa

Applications:

WB ICC IHC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:200 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com