Background:

CHIP (carboxy terminus of HSP 70-interacting protein), also designated STIP1 homology and U-box containing protein 1, HSPABP2, NY-CO-7, SDCCAG7 and STUB1, is a cytoplasmic E3 ubiquitin ligase that influences protein ubiquitylation. CHIP interacts with Smad1/Smad4 and blocks BMP signaling through the ubiquitin-mediated degradation of Smad proteins. CHIP controls both association of Hsp70/Hsp90 chaperones with ErbB2 and down-regulation of ErbB2 induced by inhibitors of Hsp90. A 1.3-kb transcript is most abundant in striated muscle (heart and skeletal muscle), with lower expression in pancreas and brain.

Specificity:

STUB1 polyclonal antibody detects endogenous levels of STUB1 protein.

Alternative names:

STUB1, CHIP, PP1131, Antigen NY CO 7, Antigen NY-CO-7, C terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70 interacting protein, Carboxy terminus of Hsp70-interacting protein, Carboxy terminus of Hsp70p interacting protein, CHIP, CHIP, CLL associated antigen KW 8, CLL-associated antigen KW-8, E3 ubiquitin protein ligase CHIP, E3 ubiquitin-protein ligase CHIP, Heat shock protein A binding protein 2 (c terminal), HSPABP2, NY CO 7, PP1131, SDCCAG7, Serologically defined colon cancer antigen 7, STIP1 homology and U Box containing protein 1, STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase, STIP1 homology and U box-containing protein 1, STUB 1, STUB1, UBOX 1, UBOX1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human STUB1 aa 1-200.

Purification & Purity:

ProA affinity purified

Molecular weight:

35 kDa

Applications:

WB ICC IF IHC IP FC

Usage:

WB:1:1,000-1:2,000 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com