Background:

Stress-induced-phosphoprotein 1 (STI1) functions as a co-chaperone for HSP70 and HSP90 during heat shock response. STI1 exists as either a monomer or a dimer, and this conformational flexibility facilitates its function in organizing HSP70/HSP90. HSP90 acts as an ATPase, and requires the recruitment of client proteins and proper conformation to function. STI1 acts as a "scaffold" for client protein recruitment to the relaxed, ADP-bound conformation of HSP90, thus suppressing ATP turnover during the loading phase and allowing proper function.

Specificity:

STIP1 polyclonal antibody detects endogenous levels of STIP1 protein.

Alternative names:

STI1, Hop, STIP1, Epididymis secretory sperm binding protein Li 94n, HEL S 94n, Hop, Hsc70/Hsp90 organizing protein, Hsc70/Hsp90-organizing protein, IEF SSP 3521, NY REN 11 antigen, P60, Renal carcinoma antigen NY-REN-11, STI1, STI1L, STIP1, STIP1, Stress induced phosphoprotein 1, Stress-induced-phosphoprotein 1, Transformation sensitive protein IEF SSP 3521, Transformation-sensitive protein IEF SSP 3521,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

63 kDa

Applications:

WB IHC FC IP ICC

Usage:

WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:50-1:100 ICC:1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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