Background:

Nuclear receptors for steroids, thyroid hormones and retinoic acids are ligand-dependent transcription factors that activate transcription through specific DNA binding sites in their target genes. Several related transcriptional coactivators and corepressors have been described that work in concert with the steroid receptor family to either induce or repress transcription from hormone-responsive elements. This family includes GRIP1 (for GR interacting protein 1, also designated NCoA-2 or Tif2); SRC-1 (for steroid receptor coactivator-1, also designated NCoA-1); RAC3 (also designated AIB1, for amplified in breast cancer, or ACTR), which displays elevated expression in estrogen receptor positive ovarian and breast cancers; and p/CIP (for p300/CBP/Co-Integrator Protein), which is required for the transcriptional activation of p300/CBP-dependent transcription factors

Specificity:

SRC1 polyclonal antibody detects endogenous levels of SRC1 protein.

Alternative names:

NCoA-1, bHLHe74, SRC-1, NCOA1, BHLHE74, SRC1, bHLHe74, Class E basic helix-loop-helix protein 74, F SRC 1, Hin 2 protein, Hin2 protein, MGC129719, MGC129720, mNRC 1, NCoA 1, NCoA-1, Ncoa1, NCOA1, Nuclear receptor coactivator 1, Nuclear receptor coactivator protein 1, NY REN 52 antigen, Protein Hin 2, Protein Hin-2, Protein Hin2, Renal carcinoma antigen NY REN 52, Renal carcinoma antigen NY-REN-52, RIP 160, RIP160, SRC 1, SRC-1, Steroid receptor coactivator 1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

156 kDa

Applications:

WB IHC IP

Usage:

WB:1:500-1:2,000 IHC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com