Background:

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Specificity:

SOCS2 polyclonal antibody detects endogenous levels of SOCS2 protein.

Alternative names:

SOCS-2, CIS-2, SSI-2, SOCS2, CIS2, SSI2, STATI2, CIS 2, CIS-2, CIS2, Cish 2, Cish2, Cytokine inducible SH2 protein 2, Cytokine-inducible SH2 protein 2, SOCS 2, SOCS-2, Socs2, SOCS2, SSI 2, SSI-2, SSI2, STAT induced STAT inhibitor 2, STAT-induced STAT inhibitor 2, STATI 2, STATI2, Suppressor of cytokine signaling 2,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human SOCS2 1-150aa.

Purification & Purity:

ProA affinity purified

Molecular weight:

22 kDa

Applications:

WB ICC IF IP

Usage:

WB:1:500-1:2,000 ICC:1:50-1:200 IP:1:10-1:50

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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