Background:

The Snail family of developmental regulatory proteins is a group of widely conserved zinc-finger proteins that regulate transcription and include the mammalian proteins SLUG, SNAI 1, the human homolog of Drosophila SNAIL, and Smuc. SNAI 1 and SLUG are expressed in placenta and adult heart, liver, and skeletal muscle. SNAI 1, and the corresponding mouse homolog Sna, each contain three classic zinc fingers and one atypical zinc finger, while SLUG contains five zinc finger regions and a transcriptional repression domain at the amino terminus, which enables SLUG to act as a negative regulator of gene expression. SLUG is implicated in the generation and migration of neural crest cells in human embryos and also contributes to limb bud development. In addition, SLUG also constitutes a cellular anti-apoptotic transcription factor that effectively prevents apoptosis in murine pro-B cells deprived of IL-3. The Snail-related gene from murine skeletal muscle cells, Smuc, is highly expressed in skeletal muscle and thymus and can, likewise, repress gene transcription. Smuc preferentially associates with CAGGTG and CACCTG E-box motifs (CANNTG) on DNA and involves the five putative DNA-binding zinc finger domains at the C-terminal region of Smuc.

Specificity:

SNAIL polyclonal antibody detects endogenous levels of SNAIL protein.

Alternative names:

Protein sna, SNAI1, SNAH, dJ710H13.1, Protein sna, Protein snail homolog 1, Protein snail homolog, SLUGH2, SNA, Sna protein, SNAH, SNAI, snai1, SNAI1, Snail 1 homolog, Snail 1 zinc finger protein, SNAIL, Snail family transcriptional repressor 1, Snail homolog 1 (Drosophila), SNAIL, Drosophila, homolog of, 1, SNAIL1, Zinc finger protein SNAI1,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Peptide

Purification & Purity:

Peptide affinity purified

Molecular weight:

29 kDa, additional band 35 kDa

Applications:

WB ICC IHC

Usage:

WB:1:500-1:1,000 ICC:1:50-1:100 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com