Background:

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Specificity:

SFRP1 polyclonal antibody detects endogenous levels of SFRP1 protein.

Alternative names:

FRP-1, sFRP-1, SARP-2, SFRP1, FRP, FRP1, SARP2, Frizzled related protein 1, FRP 1, FRP, FRP-1, FRP1, FrzA, SARP 2, SARP-2, SARP2, Secreted apoptosis related protein 2, Secreted apoptosis-related protein 2, Secreted frizzled related protein 1, Secreted frizzled related protein, Secreted frizzled-related protein 1, SFRP 1, sFRP-1, SFRP1, SFRP1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Peptide

Purification & Purity:

Peptide affinity purified

Molecular weight:

35 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500-1:1,000 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com