Background:

The stromal cell derived factor 1 (SDF1, CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors. The SDF1 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells. SDF1 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells. Many cancer cells express CXCR4, suggesting that SDF1 plays a role in cancer metastasis. Alternative splicing and differential processing during maturation produce a pair of SDF1 isoforms (SDF1α and SDF1β) that have different properties and biological activities. Additional isoforms of SDF1 have been reported.

Specificity:

SDF1 polyclonal antibody detects endogenous levels of SDF1 protein.

Alternative names:

SDF-1, hSDF-1, IRH, hIRH, PBSF, CXCL12, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1, AI174028, C-X-C motif chemokine 12, Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1), Chemokine (C-X-C motif) ligand 12, Chemokine CXC motif ligand 12, cxcl12, hIRH, hSDF-1, Intercrine reduced in hepatomas, IRH, OTTHUMP00000019491, PBSF, Pre-B cell growth-stimulating factor, SCYB12, SDF 1, SDF-1, SDF-1-alpha(3-67), SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, Stromal cell-derived factor 1, Stromal cell-derived factor 1 delta, Stromal cell-derived factor 1 gamma, Stromal cell-derived factor 1a, Stromal cell-derived factor-1 alpha, Thymic lymphoma cell-stimulating factor, Tlsf, TLSF-a, TLSF-b, Tlsfa, Tlsfb, TPAR1,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

11 kDa

Applications:

WB ICC/IF

Usage:

WB:1:1,000-1:2,000 ICC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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