Background:

Proteolytic degradation by the ubiquitin (Ub) system is essential for normal cell cycle progression, cellular differentiation and stress responses. Proteins conjugated to Ub are marked for progressive degradation by the 26S Proteasome. AOS-1, also designated SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, belongs to the ubiquitin-activating E1 family of proteins and plays an important role in the first step of the UBL1 conjugation pathway. AOS-1, which is a dimeric enzyme, functions as a UBLI E1 ligase, mediating the ATP-dependent activation of UBL1. AOS-1 can bind with UBLE1A and UBLE1B to form a heterodimer which can bind UBL1.

Specificity:

SAE1 polyclonal antibody detects endogenous levels of SAE1 protein.

Alternative names:

SAE1, AOS1, SUA1, UBLE1A, Activator of SUMO1, AOS1, HSPC140, Sae1, SAE1, Sentrin/SUMO activating protein AOS1, SUA1, SUMO 1 activating enzyme E1 N subunit, SUMO 1 activating enzyme subunit 1, SUMO-activating enzyme subunit 1, Ubiquitin like protein SUMO1 activating enzyme, Ubiquitin-like 1-activating enzyme E1A, UBL E1A, UBLE1A,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human SAE1 aa 150-300.

Purification & Purity:

ProA affinity purified

Molecular weight:

38 kDa

Applications:

WB FC

Usage:

WB:1:500-1:2,000 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com