Background:

Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma laminin-binding protein) and is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Additionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.

Specificity:

RPSA polyclonal antibody detects endogenous levels of RPSA protein.

Alternative names:

37LRP, LRP/LR, 67LR, LamR, LBP/p40, RPSA, 34/67 kDa laminin receptor, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 37LRP, 40S ribosomal protein SA, 67 kDa laminin receptor, 67LR, Colon carcinoma laminin binding protein, Colon carcinoma laminin-binding protein, LAMBR, Laminin receptor 1, Laminin-binding protein precursor p40, LAMR 1, LamR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, Multidrug resistance associated protein MGr1 Ag, Multidrug resistance associated protein MGr1Ag, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, p40, Ribosomal Protein SA, rpsA, RSSA, SA,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

40 kDa

Applications:

WB ICC/IF IHC IP FC

Usage:

WB:1:1,000-1:2,000 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com