Bioworld Technology

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RNF40 polyclonal antibody BS91173

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Specifications

size	50ul/100ul

Background:

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specificity:

RNF40 polyclonal antibody detects endogenous levels of RNF40 protein.

Alternative names:

BRE1-B, RBP95, RNF40, BRE1B, KIAA0661, 95 kDa retinoblastoma associated protein, 95 kDa retinoblastoma protein binding protein, 95 kDa retinoblastoma-associated protein, BRE 1B, BRE1 B, BRE1 E3 ubiquitin ligase homolog B, BRE1-B, BRE1B, BRE1B, DKFZp686K191, E3 ubiquitin protein ligase BRE1B, E3 ubiquitin-protein ligase BRE1B, KIAA0661, MGC13051, Rb associated protein, RBP 95, RBP95, RING finger protein 40, Ring finger protein 40 E3 ubiquitin protein ligase, RNF 40, Rnf40, STARING antibody

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human RNF40 aa 200-400.

Purification & Purity:

Protein A purified.

Molecular weight:

114 kDa

Applications:

WB IP IHC

Usage:

WB:1:1,000-1:2,000 IP:1:10-1:50 IHC:1:50

Storage:

Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com