Background:

E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable).

Specificity:

RING2 polyclonal antibody detects endogenous levels of RING2 protein.

Alternative names:

HIP2-interacting protein 3, RING1b, RNF2, BAP1, DING, HIPI3, RING1B, BAP 1, BAP1, DING, DinG protein, E3 ubiquitin protein ligase RING 2, E3 ubiquitin protein ligase RING2, E3 ubiquitin-protein ligase RING2, HIP2 interacting protein 3, HIP2-interacting protein 3, HIPI 3, HIPI3, Huntingtin interacting protein 2 interacting protein 3, Huntingtin-interacting protein 2-interacting protein 3, OTTHUMP00000060668, Polycomb M33 interacting protein Ring 1B, Polycomb M33 interacting protein Ring1B, Protein DinG, RING 1B, RING 2, RING finger protein 1B, RING finger protein 2, RING finger protein BAP 1, RING finger protein BAP-1, RING finger protein BAP1, RING1b, RING2, RNF 2, Rnf2,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

38 kDa

Applications:

WB IHC

Usage:

WB:1:500-1:1,000 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com