Background:

Recombination signal binding protein Jκ (RBP-Jκ), also designated KBF2 or CBF1, is the mammalian homolog of the Drosophila suppressor of hairless (Su(H)), a protein involved in the development of the peripheral nervous system. RBP-Jκ is ubiquitously expressed in mammalian tissues and is involved in the regulation of gene expression. RBP-Jκ has been shown to directly interact with the intercellular domain of the cell surface receptor Notch 1. Proteolytically cleaved Notch 1 translocates to the nucleus, where it binds DNA-bound RBP-Jκ and activates transcription of target genes. These genes include NFκB p52 and the Epstein-Barr virus (EBV) protein EBNA-2, both of which contain RBP-Jκ-binding sequences within their promoter regions.

Specificity:

RBPJK polyclonal antibody detects endogenous levels of RBPJK protein.

Alternative names:

RBP-J, RBP-JK, RBPJ, IGKJRB, IGKJRB1, RBPJK, RBPSUH, AI843960, AOS3, CBF 1, CBF-1, CBF1, csl, IGKJRB, IGKJRB1, J kappa recombination signal binding protein, J kappa-recombination signal-binding protein, KBF2, NY REN 30 antigen, RBP J, RBP J kappa, RBP JK, RBP-J, RBP-J kappa, RBP-JK, Rbpj, RBPJK, RBPSUH, recombination signal binding protein for immunoglobulin kappa J region, Recombining binding protein suppressor of hairless, Renal carcinoma antigen NY-REN-30, SUH, SUH,

Species reactivity:

Human

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

55 kDa

Applications:

WB

Usage:

WB:1:1,000-1:5,000

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com