Background:

Regulatory associated protein of FRAP, also designated Raptor, is a binding partner for mammalian target of rapamycin kinase (FRAP), and is essential for FRAP signalling in vivo. Raptor binding to FRAP is critical for FRAP-catalysed substrate phosphorylation of 4E-BP1. The raptor-FRAP complex is nutrient-sensitive and is important for a mechanism by which cells coordinate cell growth and size with changing environmental conditions. Raptor serves as a negative regulator of FRAP kinase activity under nutrient-deprived conditions and is an important component in the FRAP pathway. Raptor is highly expressed in skeletal muscle and to a lesser extent in brain, kidney, lung and placenta.

Specificity:

Raptor polyclonal antibody detects endogenous levels of Raptor protein.

Alternative names:

Raptor, RPTOR, KIAA1303, RAPTOR, KIAA1303, KOG1, Mip1, P150 target of rapamycin (TOR) scaffold protein, p150 target of rapamycin (TOR) scaffold protein containing WD repeats, P150 target of rapamycin (TOR)-scaffold protein, Raptor, Regulatory associated protein of mTOR, Regulatory associated protein of MTOR complex 1, Regulatory-associated protein of mTOR, RPTOR, RPTOR,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide within human Raptor aa 100-150.

Purification & Purity:

Peptide affinity purified.

Molecular weight:

131 kDa

Applications:

WB ICC IHC FC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:50-1:200 FC:1:50-1:100

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

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