Background:

Mrnp41 (mRNA-binding protein, 41-KD), also known as Rae1 protein homolog and mRNA export factor, is a 368 amino acid protein that binds mRNA and is involved in nucleocytoplasmic transport. Though characterized in both the nucleus and cytoplasm, mrnp41 is primarily localized to the nuclear pore complex in the nuclear envelope. Mutations in mrnp41 may result in the accumulation of poly(A)-containing mRNA in the nucleus, further supporting the role of mrnp41 as a primary nuclear exporter of mRNA. Along with Nup98, mrnp41 has been shown to regulate E-cadherin, an activating subunit of the anaphase-promoting complex complex, which results in the prevention of securin degradation, therefore suggesting that mrnp41 may play a potential role in maintaining euploidy. Also, during mitosis, both mrnp41 and NuMA have been shown to be required for bipolar spindle formation.

Specificity:

Rae1 polyclonal antibody detects endogenous levels of Rae1 protein.

Alternative names:

RAE1, MRNP41, dJ481F12.3, dJ800J21.1, FLJ30608, Homolog of yeast Rae1 (Bharathi) mRNA associated protein of 41 kDa (Kraemer), Homolog of yeast Rae1 mRNA associated protein of 41 kDa, MGC117333, MGC126076, MGC126077, MIG 14, MIG14, Migration inducing gene 14, Mnrp 41, Mnrp41, mRNA associated protein mrnp 41, mRNA binding protein 41 kD, mRNA export factor, mRNA export protein, mRNA-associated protein mrnp 41, MRNP 41, MRNP41, RAE 1, RAE1 (RNA export 1 S.pombe) homolog, rae1, RAE1 homolog, Rae1 protein homolog, RAE1 RNA export 1 homolog (S. pombe), RAE1 RNA export 1 homolog, RAE1L, RNA export 1, RNA export 1 homolog,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Synthetic peptide within human Rae1 aa 330-368.

Purification & Purity:

Peptide affinity purified.

Molecular weight:

41 kDa

Applications:

WB ICC FC

Usage:

WB:1:500-1,000 ICC:1:50-1:200 FC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

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