Background:

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Specificity:

PSMA1 polyclonal antibody detects endogenous levels of PSMA1 protein.

Alternative names:

PROS-30, PSMA1, HC2, NU, PROS30, PSC2, 30 kDa prosomal protein, HC 2, HC2, Macropain subunit C2, Macropain subunit nu, MGC14542, MGC14575, MGC14751, MGC1667, MGC21459, MGC22853, MGC23915, Multicatalytic endopeptidase complex subunit C2, NU, PROS 30, PROS-30, PROS30, Proteasome (prosome macropain) subunit alpha type 1, Proteasome alpha 1 subunit, Proteasome component C2, Proteasome nu chain, Proteasome subunit alpha type 1, Proteasome subunit alpha type I, Proteasome subunit alpha type-1, Proteasome subunit nu, Protein P30 33K, PSA1, PSC 2, PSC2, PSMA 1, psmA1,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

30 kDa

Applications:

WB IHC FC IP

Usage:

WB:1:500-1:2,000 IHC:1:50-1:200 FC:1:50-1:100 ICC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com