Bioworld Technology

Bioworld Technology is manufacturer of over 15,000 highly purified Monoclonal and Polyclonal Antibodies, Peptides, Proteins, and other related Research Products. Their products are used in all biological fields. An important focus in research taking place today is in work investigating Signal transduction pathways, Cardiac markers, Neuroscience as well as Stem cell research. Bioworld Technology is committed to providing customers with innovative research tools and to helping scientists determine the mechanisms of cell function and disease.
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PRTN3 polyclonal antibody BS91120

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Specifications

size	50ul/100ul

Background:

The major features of Wegener granulomatosis are necrotizing granulomatous lesions, which most often affect the upper and lower airways and are associated with vasculitis, necrotizing glomerulonephritis and pulmonary capillaritis. The antigen responsible for this disease is Proteinase 3 (PR3, P29 or myeloblastin), which is one of the antibiotic proteins of neutrophilic granules belonging to the serine protease family. It is closely related to two others: Neutrophil Elastase and azurocidin. All three genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. PR3 is a neutrophil protein which is able to cleave elastin and is involved in proliferation of human leukemia cells. PR3 is expressed specifically in immature myeloid cells and is a G-CSF-responsive protein critical to factor-independent growth. The genes for all three of the related serine protease family members are located in a cluster on the tip of the short arm of human chromosome 19.

Specificity:

PRTN3 polyclonal antibody detects endogenous levels of PRTN3 protein.

Alternative names:

PR-3, PR3, NP-4, PRTN3, MBN, ACPA, AGP 7, AGP7, AGP7 serine proteinase, Azurophil Granule Protein 7, C ANCA, C ANCA antigen, C-ANCA antigen, CANCA, EC 3.4.21.76, Leukocyte proteinase 3, MBN, MBT, MBT WEGENER AUTOANTIGEN, Myeloblastin, Neutrophil proteinase 4, NP 4, NP-4, NP4, P29, PR 3, PR-3, PR3, Proteinase 3, Proteinase3, PRTN 3, Prtn3, PRTN3, Serine proteinase neutrophil Wegener granulomatosis autoantigen, Serine proteinase, neutrophil, Wegener autoantigen, Wegener granulomatosis autoantigen,

Species reactivity:

Human, Mouse

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein

Purification & Purity:

ProA affinity purified

Molecular weight:

27 kDa

Applications:

WB ICC IHC

Usage:

WB:1:500 ICC:1:50-1:200 IHC:1:100-1:500

Storage:

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

More info:

Email: info@sobekbio.com

Orders:

Email: orders@sobekbio.com