Background:

Paroxon is an organophosphorus anticholinesterase compound, used topically in the treatment of glaucoma. It is produced in vivo in mammals by microsomal oxidation of the insecticide parathion. Parathion is inert until transformed to paroxon. Paroxonase (paraoxonase or PON) is an arylesterase that is capable of hydrolyzing paroxon to produce p-nitrophenol. PONs are nonspecific and their classification is based not only on substrate specificity but also on tissue distribution, inhibition properties, and physicochemical characteristics such as electrophoretic mobility and molecular weight. In contrast to PON1, which is expressed mainly in the liver, PON2 is expressed in a variety of mouse tissues, including the pancreas. PON3 is associated with the high density lipoprotein fraction of serum. The genes which encode PON1-3 are physically linked and map to human chromosome 7q21.3.

Specificity:

PON2 polyclonal antibody detects endogenous levels of PON2 protein.

Alternative names:

PON 2, A-esterase 2, PON2, A esterase 2, A-esterase 2, Aromatic esterase 2, Paraoxonase 2, Paraoxonase nirs, PON 2, PON2, PON2, Serum aryldialkylphosphatase 2, Serum paraoxonase/arylesterase 2,

Species reactivity:

Human, Mouse, Rat

Host:

Rabbit

Ig type:

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Immunogen:

Recombinant protein within human PON2 aa 200-350.

Purification & Purity:

ProA affinity purified

Molecular weight:

38/39 kDa

Applications:

WB IHC IP

Usage:

WB:1:500-1:2,000 IP:1:10-1:50 IHC:1:50-1:200

Storage:

Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Precautions:

For research use only, not for use in diagnostic procedure.

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